ABSTRACT
Introduction: The novel coronavirus SARS-CoV-2 has caused the death of more than 5 million of people worldwide. Vaccination is the best strategy for controlling the pandemic with an estimated of more that 4 million of people completely vaccinated. The reported adverse events secondary to vaccines against SARS-CoV-2 are mainly mild and moderate, however, there are raising concerns about more severe and long-term outcomes, as well as neurological complications due to the vaccine. Method(s): We present two cases of psychogenic non epileptiform seizures (PNES) in Colombian female patients following vaccination against COVID-19. There is no evidence of similar adverse reactions reported on the literature. Discussion and conclusion: We report these events in order to help clinicians in recognizing early and properly all the possible neurological manifestations related to COVID vaccine application, which is aimed to control the current pandemic and its devastating worldwide consequences in terms of health and social issues.Copyright © 2022 Instituto Nacional de Neurologia y Neurocirurgia. All rights reserved.